Tapirof 1% Cream 30gm

Composition

• Tapinarof

Uses of Tapinar

Manage plaque psoriasis in affected individuals

Side Effects of Tapinarof

• Itching
• Redness
• Stinging sensation
• Dryness
• Rash

Quick Suggestions:

• Use mild soap while taking baths and prefer warm baths.
• Always wear loose-fitting clothes to avoid further sweat and the spread of infections.
• Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.
• Do not walk barefoot at places like gym showers to prevent infections.
• Do not scratch the affected area of the skin as it can spread the infection to other body parts.
• Avoid sharing towels, combs, bed sheets, shoes, or socks with others.
• Wash your bed sheets and towels regularly.
• Avoid or limit the intake of alcohol and caffeine.
• Do not scratch or pick your skin to avoid getting the affected area infected.
• Manage stress, eat healthily, drink plenty of water, exercise regularly, and sleep peacefully.

Indication of Tapinarof

Tapinarof is used in the treatment of psoriasis.

Pharmacology

Tapinarof is a novel therapeutic agent classified as a therapeutic aryl hydrocarbon receptor-modulating agent (TAMA). Its effectiveness in treating psoriasis is attributed to its interaction with the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor.

Mechanism of Action Upon binding to its ligand, AhR forms a heterodimer with the AhR nuclear translocator (ARNT). This complex then binds to DNA at specific recognition sites to regulate gene expression. AhR activation influences various transcription factors, including the nuclear factor κB (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2, a downstream product of AhR-induced transcription, possesses antioxidant properties that contribute to its therapeutic effects.

Role of AhR in Psoriasis Dysregulation of AhR is a hallmark of psoriasis. Patients with psoriasis exhibit higher serum concentrations of AhR. Activation of AhR in vitro has been shown to result in a gene expression profile implicated in the pathogenesis of psoriasis. Key effects of AhR activation include:

• Expansion and differentiation of Th17 and Th22 cells, which release inflammatory cytokines IL-17 and IL-22.
• Recruitment of persistent skin resident memory T cells, contributing to the chronic nature of psoriasis.

Tapinarof binds specifically to AhR and modulates a unique set of genes dysregulated in psoriasis, distinct from other AhR ligands. This specificity is crucial in its therapeutic role:

• Barrier Protein Expression: Tapinarof induces the expression of barrier proteins such as filaggrin, hornerin, and involucrin. These proteins help restore skin barrier function and epidermal health.
• Reduction of Oxidative Stress: By activating Nrf2, Tapinarof decreases oxidative stress, which is beneficial in reducing psoriatic inflammation.

The anti-inflammatory effects of Tapinarof are potentially due to its dual action on AhR and Nrf2. Not all AhR agonists activate the Nrf2 pathway; for example, 2,3,7,8-tetrachlorodibenzo-p-dioxin does not exhibit antioxidant activity post-AhR activation. The unique ability of Tapinarof to engage both AhR and Nrf2 pathways is hypothesized.

Dosage & Administration of Tapinarof

• Always use it exactly as advised by your doctor.
• Wash your hands before and after applying Tapinarof.
• It is meant only for application on the skin.
• Apply it on the area of the skin which has psoriasis (red and white scaly patches).
• You can squeeze the medicine directly on the skin or if you want you can squeeze it on your finger first.
• Apply it in a good quantity (thickly) and then gently rub it in to cover the area of psoriasis, till it disappears.
• Always wash your hands after use.

Interaction

Before taking Tapinarof, let your doctor know if you have any fungal, viral, or protozoa infections, liver, kidney diseases, hypercalcemia (high calcium levels in the blood), or hypervitaminosis D (excess Vitamin D levels in the blood).

Contraindications

Hypersensitive to any of its components.

Pregnancy & Lactation

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Precautions & Warnings

• Disclose any history of liver or kidney diseases, hypercalcemia (high calcium levels in the blood), or hypervitaminosis D (excess Vitamin D levels in the blood) to your doctor.
• Use Tapinarof only with proper consultation and caution if you are pregnant or breastfeeding.
• Ensure Tapinarof does not come into contact with your eyes, nose, or mouth. Rinse thoroughly with water if contact occurs.
• Tapinarof is not recommended for children under 12 years of age.
• If you do not notice any improvement in your condition after using Tapinarof for one to two weeks, consult your doctor.

Storage Conditions:

Store in a cool and dry place away from sunlight